Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds


  • I.A. Farbun Institute for Sorption and Problems of Endoecology
  • V.A. Trykhlib Institute for Sorption and Problems of Endoecology




uremic toxins adsorption, amino acids adsorption, carbon adsorbents, tryptophan, arginine, indole, creatinine, vitamine B12


The paper investigates the regulation of the hydrophobicity of KARBON™ carbon adsorbents by restoring its surface during heat treatment in argon and hydrogen, as well as oxidizing it with nitric acid. The sorption capacity of KARBON™ with respect to the tryptophan, arginine, indole, creatinine and vitamin B12 as biologically active organic compounds of different molecular weight was studied. It was determined that the adsorption capacity of KARBON™ samples with respect to all the studied substances changes as follows: Ind>Cr>Trp>Arg>B12. It has been shown that the sorption capacity of argon-treated KARBON™ adsorbent at pH=7.5 is 2.6; 2.7 and 0.09 mmol/g in relation to tryptophan, creatinine and vitamin B12, respectively. The adsorption capacity of these compounds is almost unchanged when the acidity changes from 7.5 to 2.0. The results obtained allows the use of KARBON™ adsorbent as a therapeutic and/or prophylactic agent for oral administration in chronic kidney and liver diseases, as well as a hemosorbent for the purification of blood outside the human body.



R. Vanholder, R. De Smet, G. Glorieux, A. Argiles, U. Baurmeister, P. Brunet, W. Clark, G. Cohen, P.P. De Deyn, R. Deppisch, B. Descamps-Latscha, T. Henle, A. Jörres, H.D. Lemke, Z.A. Massy, J. Passlick-Deetjen, M. Rodriguez, B. Stegmayr, P. Stenvinkel, C. Tetta, C. Wanner, W. Zidek, Kidney International 63(5), 1934 (2003) (https://doi.org/10.1046/j.1523-1755.2003.00924.x).

T. Niwa, Nagoya Journal of Medical Science 72(1-2), 1 (2010) (https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7212/p001-012_Niwa.pdf).

D. Bergé-Lefranc, H. Pizzala, R. Denoyel, V. Hornebecq, J.-L. Bergé-Lefranc, R. Guieu, P. Brunet, H. Ghobarkar, O. Schäf, Microporous and Mesoporous Materials 119(1-3) 186 (2009) (https://doi.org/10.1016/j.micromeso.2008.10.016).

T. Mitome, Y. Uchida, Y. Egashira, K. Hayashi, A. Nishiura, N. Nishiyama, Colloids and Surfaces A: Physicochemical and Engineering Aspects 424(5), 89 (2013) (https://doi.org/10.1016/j.colsurfa.2013.02.022).

C. Brunori, B.F. Viola, P. Maiorca, C. Cancarini, Blood Purification 26(1), 36 (2008) (https://doi.org/10.1159/000110561).

Kh. Kurokava, K. Khibi, T. Kousaka, K. Sudzuki, Pat. 2627464C2 RU, ICP A 61 K 33/44, A 61 P 1/16, A 61 P 39/02, B 01 J 20/20, B 01 J 20/30, C 01 B 31/10. Publ. 20.11.2014, Bull. № 32;

V.A. Trykhlib, V.V. Strelko, Pat. 109548 UA, ICP А 61 K 33/44, C 01 B 31/08, B 01 J 20/20, B 01 J 20/30. Publ. 25.08.2016, Bull. № 16/2016;

F.I. Kazakov, V.V. Kirkovsky, The Medical Journal 1, 65 (2014).

Y.V. Isaieva, I.A. Farbun, V.A. Trykhlib, Theretical and Experimental Chemistry 54(6), 414 (2019) (https://doi.org/10.1007/s11237-019-09589-3).

I.A. Farbun, V.A. Trykhlib, N.N. Tsyba, Voprosy Khimii i Khimicheskoi Tekhnologii 129(2), 125 (2020).

P. Ertl, B. Rohde, P. Selzer, Journal of Medical Chemistry 43, 3714 (2000) (https://doi.org/10.1021/jm000942e).

K.S.W. Sing, D.H. Everett, R.A.W. Haul, L. Moscou, R.A. Pierotti, J. Rouquerol, T. Siemieniewska, Pure and Applied Chemistry 57(4), 603 (1985) (https://doi.org/10.1515/iupac.57.0007).

Q. Gao, W. Xu, Y. Xu, D. Wu, Y. Sun, F. Deng, W. Shen, Journal of Physical Chemistry B 112(7), 2261 (2008) (https://doi.org/10.1021/jp0763580).

B. Koubaissy, J. Toufaily, Z. Yaseen, T.J. Daou, S. Jradi, T. Hamieh, Adsorption Science and Technology 35(1-2), 3 (2017) (https://doi.org/10.1177%2F0263617416666084).

J. Kirschbaum, Analitical Profiles of Drug Substances 10, 183 (1981).

J. Goscianska, A. Olejnik, R. Pietrzak, Adsorption 19(2-4), 581 (2013) (https://doi.org/10.1007/s10450-013-9481-z).

A.L. Lehninger, Principles of Biochemistry (Worth Publishers, Inc, 1982).

P. Newmark, S. Mester, Biochimica et Biophysica Acta 343(3), 627 (1974) (https://doi.org/10.1016/0304-4165(74)90281-5).

L. Li, X. Yao, H. Li, Z. Liu, W. Ma, X. Liang, Journal of Chemical Engineering of Japan 47(1), 21 (2014) (https://doi.org/10.1252/jcej.13we193).

E.V. Veprikova, I.P. Ivanov, N.V. Chesnokov, B.N. Kuznetsov, Journal of Siberian Federal University. Chemistry 11(4), 488 (2018) (https://doi.org/10.17516/1998-2836-0093).

J-B. Yang, L-C. Ling, L. Liu, F-Y. Kang, Z-H. Huang, H. Wu, Carbon 40(6), 911 (2002) (https://doi.org/10.1016/S0008-6223(01)00222-6).

S.N. Lanin, S.A. Rychkova, A.E. Vinogradov, M.B. Viryasov, I.A. Vostrov, I.A. Shatalov, Sorbcionnye i Khromatograficheskie Processy 15(2), 179 (2015) (http://www.sorpchrom.vsu.ru/articles/20150204.pdf).



How to Cite

Farbun, I., & Trykhlib, V. (2020). Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds. Physics and Chemistry of Solid State, 21(4), 707–713. https://doi.org/10.15330/pcss.21.4.707-713



Scientific articles