Principles of Construction of Hybrid Microsystems for Biomedical Applications

  • B.S. Dzundza Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine
  • I.T. Kohut Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine
  • V.I. Holota Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine
  • L.V. Turovska Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • M.V. Deichakivskyi Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine
Keywords: sensory microsystem, non-invasive continuous monitoring, human blood glucose level, heart rate, saturation, absorption, mobile devices


The paper analyzes the existing non-invasive methods and tools for measuring and monitoring heart rate (HR), glucose saturation and human blood glucose level (BGL), shows ways of improving them to increase accuracy and expand the number of parameters obtained by these methods, which became the basis for creating a hybrid microsystem device for biomedical applications.

A block diagram of the microsystem and a prototype of software and hardware tools for continuous monitoring of heart rate, BGL, saturation level and other blood parameters by photoplethysmography (PPG) have been developed. The proposed algorithms and tools provide primary processing of signals from optical sensors, calculation of pulse wave parameters, data transmission to mobile devices and a remote server, the possibility of calibration during operation based on research results.


J.L. Moraes, M.X. Rocha, G.G. Vasconcelos, J.E. Vasconcelos Filho, V.C. de Albuquerque, A.R. Alexandria, Advances in Photopletysmography Signal Analysis for Biomedical Applications, Sensors, 18, 1894 (2018);

Komal Lawand, Shital Patil, Mahesh Parihar, Non Invasive blood glucometer, Journal of International Advance Research In Science And Engineering, 3, 12, (2014).

R.R. Javier, A.O. Baloloy, N.B. Linsangan, I.V. Villamor Portable Non-Invasive Glucometer using NearInfrared Sensor and Raspberry Pi, 4th International Conference on Electrical, Telecommunication and Computer Engineering (ELTICOM), (2020), p. 35-39;

Chinthoju Anitha, Jaya Gayatri Chekka, Ravalika Nadigepu, Harish Kuchulakanti, IoT Aided Non-invasive NIR Blood Glucose Monitoring Device, Learning and Analytics in Intelligent Systems, 82-90 (2019);

Muhibul Haque Bhuyan. A Modern, Review of the Non-Invasive Continuous Blood Glucose Measuring Devices and Techniques for Remote Patient Monitoring System, International Scholarly and Scientific Research & Innovation, 16(2), 21 (2022).

D.A. Rogatkin, Physical Foundations of Optical Oximetry, Medical Physics, 2, 97 (2012).

E.V. Kozhokhina, Non-Invasive Methods for Measuring Bilirubin, Hemoglobin, and Glucose. Hemobiliglucometer Device, Scientific and Technical Bulletin of the St. Petersburg State University of Information Technologies, Mechanics and Optics, 72(2), 157 (2011).

S. Pimentel, P. Aguero, A.Uriz, J.Bonadero, M. Liberatori, J. Castineira, Moreira Simulation of a non-invasive glucometer based on a microwave resonator sensor, Journal of Physics: Conference Series, 477, 012020 (2013);

Ju Hyeok Kwon, So Eui Kim, Na Hye Kim, Eui Chul Lee, Jee Hang Lee, Preeminently Robust Neural PPG Denoiser, Sensors, 22, 2082 (2022);

P. Bobonych, E. Bobonych, Non-Invasive Blood Glucose Monitor, Radio Amateur, 3, 6 (2009).

R. J. McNichols and G. L. Cote, Optical glucose sensing in biological fluids: an overview, Journal of Biomedical Optics, 5(1), 5 (2003).

Hannu Sorvoja, Noninvasive blood pressure pulse detection and blood pressure determination (Oulun Yliopisto, Oulu, 2006).

S. Federico, Harinath Garudadri, Noninvasive Cuffless Estimation of Blood Pressure from Pulse Arrival Time and Heart Rate with Adaptive Calibration, IEEE Computer society, l, 14 (2009).

Y.P. Saliy, B.S. Dzundza, I.S. Bylina, O.B. Kostyuk, The influence of the technological factors of obtaining on the surface morphology and electrical properties of the PbTe films doped Bi, Journal of Nano- and Electronic Physics, 8(2), 02045 (2016);

M.A. Ruvinskii, O.B. Kostyuk, B.S. Dzundza, The influence of the size effects on the termoelectrical properties of PbTe thin films, Journal of Nano- and Electronic Physics, 8(2), 02051 (2016);

D.M. Freik, B.S. Dzundza, M.A. Lopyanko, Y.S. Yavorsky, A.I. Tkachuk, R.B. Letsyn, Structure and electrical properties of thin films of pure and bismuth-doped lead telluride, Journal of Nano- and Electronic Physics, 4(2), 02012 (2012).

O.B. Kostyuk, Ya.S. Yavorsky, B.S. Dzundza, Z.M. Dashevsky, Statethis Development of thermal detector based on flexible film thermoelectric module link is disabled, Physics and Chemistry of Solid, 22(1), 45 (2021);

A. Druzhinin, I. Ostrovskii, Y. Khoverko, I. Kogut, V.Golota, Nanoscale polysilicon in sensors of physical values at cryogenic temperatures, Journal of Materials Science: Materials in Electronics, 29(10), 8364 (2018);

How to Cite
DzundzaB., KohutI., HolotaV., TurovskaL., & DeichakivskyiM. (2022). Principles of Construction of Hybrid Microsystems for Biomedical Applications. Physics and Chemistry of Solid State, 23(4), 776-784.
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