Therapeutic potential of Gynura procumbens in obesity, metabolic syndrome, and diabetes
DOI:
https://doi.org/10.15330/jpnubio.11.20-32Keywords:
obesity, metabolic syndrome, human health, Gynura procumbens, oxidative stress, antioxidantAbstract
The growing global burden of obesity, metabolic syndrome, and diabetes has led to increased interest in alternative treatment methods due to the limitations of conventional therapy, including side effects, high cost, limited long-term effectiveness, and psychological factors. As a result, researchers are increasingly turning to the search for alternative natural compounds that can provide safe and effective treatment for metabolic disorders. Among plant-based compounds, Gynura procumbens, a traditional medicinal plant from Southeast Asia used for the prevention and treatment of various diseases, including metabolic disorders, has garnered particular attention.
This review examines the therapeutic potential of G. procumbens ("longevity spinach"), a traditional medicinal plant from Southeast Asia, in the treatment of obesity, metabolic syndrome, and diabetes. The plant is rich in bioactive compounds, including flavonoids, saponins, tannins, and phenolic acids, that have the ability to influence key metabolic pathways associated with the regulation of glucose, lipid, and blood pressure levels. Recent studies shows that G. procumbens extracts have a positive impact on reducing blood glucose levels, improving insulin resistance, regulating the lipid profile, and promoting weight loss, as well as reducing oxidative stress and suppressing inflammatory processes in animal models, which holds promise for further application in the treatment of metabolic disorders.
Analyzing recent literature on animal model experiments and some preclinical and clinical trials, this review evaluates the plant's phytochemical profile, mechanisms of action, physiological effects, and safety aspects. Particular attention should be paid to determining the optimal dose, treatment duration, and potential side effects and interactions with other medications that may be used by patients. Thus, G.procumbens has the potential to become an important component in comprehensive therapeutic strategies for the treatment of obesity, diabetes, and metabolic syndrome, but further research is necessary to confirm its clinical value definitively and identify the particular active compounds.
References
Agunloye, O. M., & Oboh, G. (2018). Caffeic acid and chlorogenic acid: evaluation of antioxidant effect and inhibition of key enzymes linked with hypertension. Journal of Food Biochemistry, 42(4), e12541. https://doi.org/10.1111/jfbc.12541
Ahmad Nazri, K. A., Fauzi, N. M., Buang, F., Mohd Saad, Q. H., Husain, K., Jantan, I., & Jubri, Z. (2019). Gynura procumbens standardised extract reduces cholesterol levels and modulates oxidative status in postmenopausal rats fed with cholesterol diet enriched with repeatedly heated palm oil. Evidence-Based Complementary and Alternative Medicine, 2019, 1–15. https://doi.org/10.1155/2019/7246756
Ahmad Nazri, K. A., Haji Mohd Saad, Q., Mohd Fauzi, N., Buang, F., Jantan, I., & Jubri, Z. (2021). Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet. Pharmaceutical Biology, 59(1), 1201–1213. https://doi.org/10.1080/13880209.2021.1970199
Algariri, K., Atangwho, I. J., Meng, K. Y., Asmawi, M. Z., Sadikun, A., & Murugaiyah, V. (2014). Antihyperglycaemic and toxicological evaluations of extract and fractions of Gynura procumbens leaves. Tropical Life Sciences Research, 25(1), 75–93.
Amin, Md. Z., Afrin, M., Meghla, N. S., Nur, Md. A., Rahman, Md. M., & Uddin, M. J. (2021). Assessment of antibacterial, anti-inflammatory, and cytotoxic effects of different extracts of Gynura procumbens leaf. Current Therapeutic Research, 95, 100636. https://doi.org/10.1016/j.curtheres.2021.100636
Aung, C. L., Kawakami, F., Imai, M., Lwin, T., Kanzaki, M., Mar, O., Phyu, K. P., Thwin, M. M., & Maruyama, H. (2021). Blood glucose‐lowering effect of water and ethanolic extracts of Gynura procumbens (Lour.) Merr. Traditional & Kampo Medicine, 8(2), 138–147. https://doi.org/10.1002/tkm2.1277
Bai, R., Yao, C., Zhong, Z., Ge, J., Bai, Z., Ye, X., Xie, T., & Xie, Y. (2021). Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European Journal of Medicinal Chemistry, 213, 113165. https://doi.org/10.1016/j.ejmech.2021.113165
Bari, Md. S., Khandokar, L., Haque, E., Romano, B., Capasso, R., Seidel, V., Haque, Md. A., & Rashid, M. A. (2021). Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura. Journal of Ethnopharmacology, 271, 113834. https://doi.org/10.1016/j.jep.2021.113834
Bengin, E., Kırtepe, A., Çınar, V., Akbulut, T., Russo, L., Aydemir, İ., Yücedal, P., Aydın, S., & Migliaccio, G. M. (2024). Leptin, ghrelin, irisin, asprosin and subfatin changes in obese women: effect of exercise and different nutrition types. Medicina, 60(7), 1118. https://doi.org/10.3390/medicina60071118
Cao, M.-Y., Wu, J., Wu, L., Gu, Z., Hu, J.-W., Xie, C.-Q., & Xiong, W. (2022). Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via regulation of the PI3K/Akt and MAPK signaling pathways. Evidence-Based Complementary and Alternative Medicine, 2022, 1–10. https://doi.org/10.1155/2022/5925626
Cao, M.-Y., Wu, J., Xie, C.-Q., Wu, L., Gu, Z., Hu, J.-W., & Xiong, W. (2022). Antioxidant and anti-inflammatory activities of Gynura procumbens flowers extract through suppressing LPS-induced MAPK/NF-κB signalling pathways. Food and Agricultural Immunology, 33(1), 511–529. https://doi.org/10.1080/09540105.2022.2098935
Cao, S., Liu, M., Han, Y., Li, S., Zhu, X., Li, D., Shi, Y., & Liu, B. (2024). Effects of saponins on lipid metabolism: the gut–liver axis plays a key role. Nutrients, 16(10), 1514. https://doi.org/10.3390/nu16101514
Chaachouay, N., & Zidane, L. (2024). Plant-derived natural products: a source for drug discovery and development. Drugs and Drug Candidates, 3(1), 184–207. https://doi.org/10.3390/ddc3010011
Clemente-Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., López-Mora, C., Yáñez-Sepúlveda, R., & Tornero-Aguilera, J. F. (2023). New insights and potential therapeutic interventions in metabolic diseases. International Journal of Molecular Sciences, 24(13), 10672. https://doi.org/10.3390/ijms241310672
Garus-Pakowska, A. (2023). Metabolic diseases—a challenge for public health in the 21st century. International Journal of Environmental Research and Public Health, 20(18), 6789. https://doi.org/10.3390/ijerph20186789
Haque, E., Kamal, M. S., Tahsin, Md. R., Ahmed, R., Choudhury, J. A., Chowdhury, A. A., Kabir, S., Amran, Md. S., & Uddin, Md. S. (2021). Current knowledge regarding pharmacological profile and chemical constituents of Gynura procumbens. Current Topics in Medicinal Chemistry, 21(29), 2671–2686. https://doi.org/10.2174/1568026621666211004094902
Hassan, Z., Yam, M. F., Ahmad, M., & Yusof, A. P. M. (2010a). Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats. Molecules, 15(12), 9008–9023. https://doi.org/10.3390/molecules15129008
Hassan, Z., Yam, M. F., Ahmad, M., & Yusof, A. P. M. (2010b). Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats. Molecules, 15(12), 9008–9023. https://doi.org/10.3390/molecules15129008
Huang, X.-L., Li, X.-J., Qin, Q.-F., Li, Y.-S., Zhang, W. K., & Tang, H.-B. (2019). Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology, 239, 111916. https://doi.org/10.1016/j.jep.2019.111916
Hui-Wen Lee. (2012). Antidiabetic effect of Gynura procumbens leaves extracts involve modulation of hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats. Journal of Medicinal Plants Research, 6(5). https://doi.org/10.5897/JMPR11.1466
Jermnak, U., Supsavhad, W., Kunakornsawat, S., Jaroensong, T., Watcharasit, P., Visitnonthachai, D., Pairor, S., & Phaochoosak, N. (2022). Anti‐cancer potentials of Gynura procumbens leaves extract against two canine mammary cancer cell lines. Veterinary Medicine and Science, 8(1), 69–84. https://doi.org/10.1002/vms3.684
Jobaer, Md. A., Ashrafi, S., Ahsan, M., Hasan, C. M., Rashid, M. A., Islam, S. N., & Masud, M. M. (2023a). Phytochemical and biological investigation of an indigenous plant of Bangladesh, Gynura procumbens (Lour.) merr.: drug discovery from nature. Molecules, 28(10), 4186. https://doi.org/10.3390/molecules28104186
Jobaer, Md. A., Ashrafi, S., Ahsan, M., Hasan, C. M., Rashid, M. A., Islam, S. N., & Masud, M. M. (2023b). Phytochemical and biological investigation of an indigenous plant of Bangladesh, Gynura procumbens (Lour.) merr.: drug discovery from nature. Molecules, 28(10), 4186. https://doi.org/10.3390/molecules28104186
Kaewseejan, N., & Siriamornpun, S. (2015). Bioactive components and properties of ethanolic extract and its fractions from Gynura procumbens leaves. Industrial Crops and Products, 74, 271–278. https://doi.org/10.1016/j.indcrop.2015.05.019
Kaewseejan, N., Sutthikhum, V., & Siriamornpun, S. (2015). Potential of Gynura procumbens leaves as source of flavonoid-enriched fractions with enhanced antioxidant capacity. Journal of Functional Foods, 12, 120–128. https://doi.org/10.1016/j.jff.2014.11.001
Kamaruzaman, K. A., Aizat, W. M., & Mat Noor, M. (2018). Gynura procumbens improved fertility of diabetic rats: preliminary study of sperm proteomic. Evidence-Based Complementary and Alternative Medicine, 2018(1), 9201539. https://doi.org/10.1155/2018/9201539
Kim, H. H., Ha, S. E., Vetrivel, P., Bhosale, P. B., Kim, S. M., & Kim, G. S. (2021). Potential antioxidant and anti-inflammatory function of Gynura procumbens polyphenols ligand. International Journal of Molecular Sciences, 22(16), 8716. https://doi.org/10.3390/ijms22168716
Kim, W., Jung, H. Y., Yoo, D. Y., Kwon, H. J., Hahn, K. R., Kim, D. W., Yoon, Y. S., Choi, S. Y., & Hwang, I. K. (2021). Gynura procumbens root extract ameliorates ischemia-induced neuronal damage in the hippocampal ca1 region by reducing neuroinflammation. Nutrients, 13(1), 181. https://doi.org/10.3390/nu13010181
Krishnan, V., Ahmad, S., & Mahmood, M. (2015). Antioxidant potential in different parts and callus of Gynura procumbens and different parts of Gynura bicolor. BioMed Research International, 2015, 1–7. https://doi.org/10.1155/2015/147909
Liu, Y., You, J., Xu, W., Zhai, T., Du, C., Chen, Y., & Han, F. (2019). Gynura procumbens aqueous extract alleviates nonalcoholic steatohepatitis through CFLAR-JNK pathway in vivo and in vitro. Chinese Herbal Medicines, 11(4), 369–378. https://doi.org/10.1016/j.chmed.2019.09.005
Manogaran, M., Vuanghao, L., & Mohamed, R. (2020). Gynura procumbens ethanol extract and its fractions inhibit macrophage derived foam cell formation. Journal of Ethnopharmacology, 249, 112410. https://doi.org/10.1016/j.jep.2019.112410
Meng, X., Li, J., Li, M., Wang, H., Ren, B., Chen, J., & Li, W. (2021). Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): A comprehensive review. Journal of Ethnopharmacology, 276, 114145. https://doi.org/10.1016/j.jep.2021.114145
Mumu, S. K., Fahim, N., Win, E. H. A., Parajuli, K., Mason, L., Wendel, I., & Mustafa, A. (2023). Potentials of Gynura procumbens to modulate chronic stress and immunological responses in Oreochromis niloticus. PLOS ONE, 18(12), e0295137. https://doi.org/10.1371/journal.pone.0295137
Murugaiyah, V., Ahmed Saeed, M., Kuong, Y.-M., Murugesu, K., Parasuraman, S., Asmawi, Mohd. Z., & Sadikun, A. (2018). Lipid-lowering effect of hydroalcoholic extracts of Gynura procumbens in Chemical- and High-fat diet-induced hyperlipidemic rats. Pharmacognosy Magazine, 14(55), 184. https://doi.org/10.4103/pm.pm_451_17
Nasiruddin, M., & Sinha, S. N. (2020). Phytochemical screening and antioxidant, antibacterial efficacy of Gynura procumbens (Lour.) Merr. Asian Journal of Medical and Biological Research, 6(2), 187–195. https://doi.org/10.3329/ajmbr.v6i2.48049
Shahlehi, S., & Petalcorin, M. I. R. (2021). Activation of cholinergic pathway induced vasodilation in rat aorta using aqueous and methanolic leaf extracts of Gynura procumbens. Biomedicine & Pharmacotherapy, 143, 112066. https://doi.org/10.1016/j.biopha.2021.112066
Sutthammikorn, N., Supajatura, V., Yue, H., Takahashi, M., Chansakaow, S., Nakano, N., Song, P., Ogawa, T., Ikeda, S., Okumura, K., Ogawa, H., & Niyonsaba, F. (2021). Topical Gynura procumbens as a novel therapeutic improves wound healing in diabetic mice. Plants, 10(6), 1122. https://doi.org/10.3390/plants10061122
Tahsin, Md. R., Tithi, T. I., Mim, S. R., Haque, E., Sultana, A., Bahar, N. B., Ahmed, R., Chowdhury, J. A., Chowdhury, A. A., Kabir, S., Aktar, F., Uddin, Md. S., & Amran, Md. S. (2022). In vivo and in silico assessment of diabetes ameliorating potentiality and safety profile of Gynura procumbens Leaves. Evidence-Based Complementary and Alternative Medicine, 2022, 1–18. https://doi.org/10.1155/2022/9095504
Tan, H.-L., Chan, K.-G., Pusparajah, P., Lee, L.-H., & Goh, B.-H. (2016). Gynura procumbens: an overview of the biological activities. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00052
Tan, J. N., Husain, K., Jubri, Z., Chan, K. M., Jantan, I., & Mohd Fauzi, N. (2022). Gynura procumbens (Lour.) Merr. Extract attenuates monocyte adherence to endothelial cells through suppression of the NF-κB signaling pathway. Journal of Ethnopharmacology, 294, 115391. https://doi.org/10.1016/j.jep.2022.115391
Tan, J. N., Mohd Saffian, S., Buang, F., Jubri, Z., Jantan, I., Husain, K., & Mohd Fauzi, N. (2020). Antioxidant and anti-inflammatory effects of genus Gynura: a systematic review. Frontiers in Pharmacology, 11, 504624. https://doi.org/10.3389/fphar.2020.504624
Thomas, M. S., Calle, M., & Fernandez, M. L. (2023). Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review. Advances in Nutrition, 14(1), 44–54. https://doi.org/10.1016/j.advnut.2022.10.002
Vatashchuk, M. V., Bayliak, M. M., Hurza, V. V., Storey, K. B., & Lushchak, V. I. (2022). Metabolic syndrome: lessons from rodent and drosophila models. BioMed Research International, 2022, 1–13. https://doi.org/10.1155/2022/5850507
Wang, H., Zhou, J. W., Fu, D. H., Zhou, Y., Cheng, W. Z., & Liu, Z.-L. (2013). Gynura procumbens ethanolic extract suppresses osteosarcoma cell proliferation and metastasis in vitro. Oncology Letters, 6(1), 113–117. https://doi.org/10.3892/ol.2013.1315
Wu, T., Zhou, X., Deng, Y., Jing, Q., Li, M., & Yuan, L. (2011). In vitro studies of Gynura divaricata (L.) DC extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Journal of Ethnopharmacology, 136(2), 305–308. https://doi.org/10.1016/j.jep.2011.04.059
Ziaul, A. M., Afrin, M., Nur, Md. A., Rahman, Md. M., & Uddin, M. J. (2021). Evaluation of medicinal effects of Gynura procumbens leave extracts on oxidative, glycemic, lipidomics, and enzymatic profiles in alloxan- induced diabetic mice. 12, 876. https://doi.org/10.35248/2155-6156.21.12.876
